Prevention of Implant Failure

Implants that fight infection
from the surface out

Preimure engineers antimicrobial polymer coatings that deliver sustained local protection — so patients recover once, not twice.

Our Technology Partner with Us
>50%
of hip replacements fail within 15 years — infection is the primary driver
1000×
greater antibiotic resistance once bacteria colonise an implant surface as biofilm
6wk+
sustained release above minimum inhibitory concentration with Preimure coating
The Challenge

Why standard care is not enough

Implant-related infections create a cascade of harm that systemic antibiotics alone cannot control. The window to intervene is narrow — and current tools miss it.

Biofilm formation stages on uncoated titanium implant

Rapid Biofilm Formation

Bacteria attach to the implant surface within hours of surgery, assembling a protective matrix that conventional treatment cannot penetrate.

12 hrs to biofilm

Antibiotic Resistance

Bacteria inside a biofilm are up to 1,000× more resistant to antibiotics — rendering systemic prophylaxis ineffective once the film is established.

1000× resistance

Revision Surgeries

When infection cannot be cleared, implant removal is required. Two-stage revision means two operations, months of immobility, and far poorer outcomes.

2 surgeries → 1

Socioeconomic Burden

Fracture-related infections drive prolonged hospitalisation, repeated interventions, and excessive antibiotic use — at enormous cost to patients and health systems.

Avoidable costs
Our Technology

A dual-antibiotic polymer coating engineered at the surface

Preimure's absorbable coating delivers two antibiotics simultaneously above the minimum inhibitory concentration for more than six weeks — directly at the implant surface where infection originates.

Sustained >6-week ReleaseActive well beyond the critical post-operative window when systemic prophylaxis has already stopped.
Dual-antibiotic DeliverySimultaneous release of two antibiotic classes suppresses resistance development even in high-risk patients.
Single-stage Revision EnablerEliminates antibiotic spacers and second operations — patients go home sooner with maintained local control.
Biodegradable & BiocompatibleThe coating degrades naturally after its active window. No secondary procedure required.
Biofilm prevention by dual-antibiotic-releasing polymer coating
Development Path

From bench to bedside

I

Surface Engineering

Coating formulations tuned to specific implant materials, geometries, and surface finishes.

II

In Vitro Validation

Release kinetics and bacterial inhibition measured across a library of clinically relevant strains.

III

Preclinical Studies

Biocompatibility, osseointegration support, and coating durability evaluated in vivo.

IV

Clinical Translation

Orthopaedic and trauma centre partnerships to advance into first-in-human trials.

Applications

Three high-impact clinical areas

Our coating platform is designed for the full spectrum of metallic orthopaedic and trauma implants — wherever infection changes patient outcomes most.

Internal fixation — intramedullary tibial nail
01 / 03

Internal Fixation Devices

Preimure is developing an antimicrobial intramedullary tibial nail for high-energy trauma such as open fractures from road accidents — where infection risk is critically elevated and staged reconstruction often becomes inevitable.

The nail combines mechanical stabilisation with local infection control, lowering fracture-related infection rates and preserving limb function without complex staged procedures.
Hip and knee revision surgery
02 / 03

Hip and Knee Revision Surgery

With sustained antimicrobial release active for more than six weeks, Preimure's coating enables single-stage revision of infected hip and knee prostheses — replacing the standard two-operation protocol.

Patients undergo thorough debridement and immediate reimplantation in one procedure, going home sooner with maintained local infection control and a significantly shorter hospital stay.
Patient-specific implant
03 / 03

Patient-Specific Implants

Complex, large-surface patient-specific designs involve longer surgeries, larger wounds, and higher infection exposure. Preimure's local antimicrobial platform is uniquely suited to these cases.

Sustained surface-level anti-infective release prevents bacterial colonisation and implant-related infection, supporting safer outcomes in these uniquely demanding reconstructive procedures.
Partners & Supporters

Built with the right collaborators

About Preimure

Built on clinical urgency

Preimure was founded to solve a problem that affects hundreds of thousands of patients every year. Despite decades of advances in implant design and surgical technique, implant-related infection remains one of the most devastating and costly complications in orthopaedics.

Our interdisciplinary team combines surface chemistry, microbiology, biomaterials science, and clinical orthopaedics to translate a clear scientific insight into a scalable patient solution.

We are actively seeking research partnerships, clinical collaborators, and strategic investors to advance our coating toward regulatory approval.

Get in Touch
IMPLANT Research Academic & Clinical Industry Manufacturers Funding Grants & Investment Regulatory EU MDR Pathway

Ready to eliminate implant infections?

Whether you are a surgeon, implant manufacturer, researcher, or investor — we want to hear from you.

Contact Preimure